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Plasma DDS concentrations were determined fluorometrically in mice fed continuously with 0.0 1% of the drug in their diet. They averaged 0.74 J.1.g per m!. (-2) Since it is known that the multiplication of My co. leprae in the mouse footpad system is inhibited by feeding 0.000 1% DDS but not by 0.0000 1% DDS in the diet, it was concluded that the MIC of DDS against My co. leprae must be less than 0.01 J.1.g per m!. .£3) The half-life of DDS in the mouse was determined after intraperitonealdoi:10.5935/0305-7518.19710013 fatcat:xiv4xyxk4zbkjnzodvqjyooiki