Region-specific activators of meiotic recombination in Schizosaccharomyces pombe

L C DeVeaux, G R Smith
1994 Genes & Development  
Schizosaccharomyces pombe rec mutants were previously isolated on the basis of their deficiency in meiotic recombination at the ade6 locus. We surveyed their meiotic recombination deficiencies at and between other loci. In reclO mutants recombinant frequencies in the ~2-Mb region surrounding the ade6 locus were reduced 10-to 100-fold, but recombinant frequencies at or between nine other unlinked loci were reduced <3-fold. The reclO mutations are recessive and are on chromosome I; the ade6
more » ... e I; the ade6 region is on chromosome III. These results indicate that the reclO gene product is required for activation of meiotic recombination in the ~2-Mb region surrounding ade6 but not in the other regions surveyed. Similar ade6 regional specificities were observed for rec8 and recll. We infer that there are multiple activators of meiotic recombination, each specific for a limited set of loci, and we discuss how these regional activators may work.
doi:10.1101/gad.8.2.203 pmid:8299939 fatcat:4aefhl26pnd6hpkcr7tgf3iqry