Trypanocidal Activity of Quinonemethide Triterpenoids from Cheiloclinium cognatum (Hippocrateaceae)

Luciano M. Liaõ, Gilmar A. Silva, Marcos R. Monteiro, Sérgio Albuquerque
2008 Zeitschrift für Naturforschung C - A Journal of Biosciences  
We report the trypanocidal activity of quinonemethide triterpenoids isolated from root extracts of Cheiloclinium cognatum, a plant of the Hippocrateaceae family, collected in the Cerrado Reserve at Universidade Federal de Goiás, Brazil. The trypanocidal activity assays showed an effect on the blood trypomastigote forms of the Y strain of Trypanosoma cruzi where tingenone and tingenol demonstrated activity on the parasite. Their structures were elucidated on the basis of spectral data,
more » ... ral data, particularly COSY, HMQC and HMBC experiments, and chemical transformations
doi:10.1515/znc-2008-3-408 fatcat:ouybtnlmejepnlywqqo5n65j3y