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Rapid Motor Fluctuations Reveal Short-Timescale Neurophysiological Biomarkers of Parkinson's Disease
[article]
2020
medRxiv
pre-print
Identifying neural activity biomarkers of brain disease is essential to provide objective estimates of disease burden, obtain reliable feedback regarding therapeutic efficacy, and potentially to serve as a source of control for closed-loop neuromodulation. In Parkinson's Disease (PD), microelectrode recordings (MER) are routinely performed in the basal ganglia to guide electrode implantation for deep brain stimulation (DBS). While pathologically-excessive oscillatory activity has been observed
doi:10.1101/2020.03.04.20024869
fatcat:hogyk5nqwzghjaigefoi6samwm