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Journal of Virology
Human papillomavirus type 16 (HPV16) early proteins E6 and E7 have been implicated in maintenance of the malignant phenotype in cervical cancer. Transforming growth factors beta one and two (TGFI3s 1 and 2), polypeptides that regulate cellular growth and differentiation, reversibly inhibited expression of the HPV16 E6 and E7 genes in several immortal genital epithelial cell lines. Loss of E6 and E7 protein expression followed a dramatic timeand dose-dependent decrease in E6 and E7 RNA levelsdoi:10.1128/jvi.64.10.4767-4775.1990 fatcat:7e2zwyaau5fyjpuc643iskrwyq