An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity

Jia-Hao Liang, Xiao-Kui Huo, Zhong-Bin Cheng, Cheng-Peng Sun, Jian-Chao Zhao, Xiao-Hui Kang, Tian-Yuan Zhang, Zhong-Jian Chen, Tian-Mei Yang, Ying-Ying Wu, Xiao-Peng Deng, Yi-Xuan Zhang
2018 Figshare  
One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans,
more » ... dida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 μg/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking.
doi:10.6084/m9.figshare.7093874.v1 fatcat:3hnpr425xbfhncudazo4k2auee