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The pentavalent antimonial compounds Glucantime® and Pentostam® are the first line drugs used in anti-Leishmania treatment. However, no in vivo studies have compared the efficacy and toxicity of these drugs where host variability has been controlled. Biochemical studies of Leishmania have detected differences between the two drugs with regard to DNA topoisomerase I inhibition, a phenomenon that possibly impacts treatment efficacy. To evaluate the clinical efficacy, hamsters were infecteddoi:10.7705/biomedica.v24i4.1289 fatcat:pfafkpixw5h33ac55pbrq37jie