Eficacia y toxicidad de los antimoniales pentavalentes (Glucantime y Pentostam) en un modelo animal de leishmaniasis cutánea americana: aplicación de la luminometría

Hector Hernán Henao, Yaneth Osorio, Nancy Gore Saravia, Arlen Gómez, Bruno Travi
2004 Biomédica: revista del Instituto Nacional de Salud  
The pentavalent antimonial compounds Glucantime® and Pentostam® are the first line drugs used in anti-Leishmania treatment. However, no in vivo studies have compared the efficacy and toxicity of these drugs where host variability has been controlled. Biochemical studies of Leishmania have detected differences between the two drugs with regard to DNA topoisomerase I inhibition, a phenomenon that possibly impacts treatment efficacy. To evaluate the clinical efficacy, hamsters were infected
more » ... ere infected intradermally in the right hind foot with 106 promastigotes of a wild type or luciferase-transfected Leishmania panamensis. At three
doi:10.7705/biomedica.v24i4.1289 fatcat:pfafkpixw5h33ac55pbrq37jie