Study and improvement of spectrophotometric and HPLC methods for the determination of nitazoxanide in pharmaceutical preparations

Chagam Reddy, Muni Reddy, Gopireddy Subbareddy
Journal of Chemical and Pharmaceutical Research   unpublished
The different assay methods for the determination of Nitazoxanide in pharmaceutical preparations have been reviewed. The determination of percentage purity of Nitazoxanide has been described by non-aqueous titration method. In this study, Nitazoxanide from commercial pharmaceutical preparations was determined quantitatively employing the modified spectrophotometric and HPLC methods and the methods were compared for their accuracy, specificity and rapidity. The results of both methods were
more » ... methods were reproducible and within the official limits, however HPLC method has been proved more authentic as it can be used for the determination of percentage purity of raw material of Nitazoxanide and also in combination with other drugs