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Rapid and quantitative analysis of metabolites in fermentor broths using pyrolysis mass spectrometry with supervised learning: application to the screening of Penicillium chrysogenum fermentations for the overproduction of penicillins
1995
Analytica Chimica Acta
The combination of pyrolysis mass spectrometry (PyMS) and artificial neural networks (ANNs) can be used to quantify levels of penicillins in strains of Penicillium chrysogenum and ampicillin in spiked samples of Escherichia coli. Four P. chrysogenum strains (NRRL 1951, Wis Q176, Pl, and P2) were grown in submerged culture to produce penicillins, and fermentation samples were taken aseptically and subjected to PyMS. To deconvolute the pyrolysis mass spectra so as to obtain quantitative
doi:10.1016/0003-2670(95)00170-5
fatcat:nhd2hekuqzfhpnn4fakrpqltom