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2014): Study on genetic variability in MHC-DRB1 second exon in makuie sheep breed population. Genetika, Vol 46, No. 1, In the present study polymorphism of the exon 2 of MHC (Major Histocompatibility Complex) gene in Makuie sheep breed was studied. Genomic DNA from blood samples of 90 sheep was extracted and a 279 bp MHC exon 2 fragment was amplified using polymerase chain reaction (PCR). PCR products were subjected to enzymatic digestion using RsaIdoi:10.2298/gensr1401269a fatcat:ztolapvgybc6zidzbeorpupmpm