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Type-2 diabetes mellitus (DM2) is a major risk factor for the development of coronary artery disease (CAD) and subsequent myocardial infarction (MI). Because the pro-inflammatory cytokine tumor necrosis factor α (TNFα) takes part in several stages of the development of atherosclerosis, we investigated the association of the TNFα gene G(-308)A polymorphism with MI in 142 DM2 patients and in 310 patients who had had DM2 for over 10 years with no clinical signs of CAD and measured the serum TNFαdoi:10.2478/v10034-008-0022-0 fatcat:zgrmes75nzaqdf6mr3zglt63wa