Neurologic uses of botulinum neurotoxin type A

John P Ney
2008 Neuropsychiatric Disease and Treatment  
This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical trials (as appropriate), including facial movement disorders, focal neck and limb dystonias, spasticity,
more » ... tonias, spasticity, hypersecretory syndromes, and pain.
doi:10.2147/ndt.s1612 fatcat:iz2btb5u65eilc5rias6uzyuqq