Chemical constituents from plant endophytic fungus Alternaria alternata

Ju-Tao Wang, Zong-Hui Ma, Guo-Kai Wang, Feng-Qing Xu, Yang Yu, Gang Wang, Dai-Yin Peng, Jin-Song Liu
2019 Figshare  
Five new natural compounds (1–5) along with four known ones, involving dibenzo-α-pyrone derivatives, a benzo-γ-pyrone derivative and an amide-type compound were obtained from Alternaria alternata, an endophyte isolated from Paeonia lactiflora. The structures of these isolates were elucidated by intensive analysis of spectroscopic data including NMR, HRMS (ESI and EI), UV and IR spectra. Compounds (1–4) were evaluated for their cytotoxicities against five selected human tumourtumour cell lines
more » ... tumour cell lines (A-549, MDA-MB-231, MCF-7, KB and KB-VIN), and compound 3 exhibited activities against MDA-MB-231and MCF-7 with IC50 values of 20.1 μM and 32.2 μM.
doi:10.6084/m9.figshare.8870498 fatcat:gsnskmicsjhmlmhi35mxuoopty