Internet Archive Scholar

Quantitative Studies of the Conversion of C3PA (GBG) to C3A (GGG)

Paul H. Lambert, L. Perrin, J. C. Cerottini
1973 Journal of Immunology  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (1.7 MB)
https://web.archive.org/web/20230102231750/https://watermark.silverchair.com/ji1110010307b.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAABJEwggSNBgkqhkiG9w0BBwagggR-MIIEegIBADCCBHMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMFNaQB1_x1HioCVsDAgEQgIIERLXJcHl0ntOOOmC4Iqk0NerTRpO-ClkHUfLO4BYyxjCLBbOeU040NqxxrDIxj2V3TvN3edPBf17HhhEV5wRqmWjN0U2FZMcz0sFhfkzDyFUYqGvnFiAL7KbRTNRD7cQ3dxTNq49BTW7bPwMNa4mzkG10ezuoe6w1nyLrVPE-1rBdwEqlRY_LbEji6bBzrQ6Z3LDGcYkx0es9FPxNkGe_ra6o2rCF5Kn_y5mc1R3y_2EzQUTqxYx0QLF1KLWzwpaq7ZI_5Kbxgb6gKXiBZXAxIDfG5nrtIEpKVIiAVJs9IJTifpQUiCSCPXVljDl7p-IWPfxqaeLb63G-FeWNfi5UpV5PxzcpepuS3z5DLV6J5SSP2qVU1od7KArglP95B8mOrhhSJFtAmrAFUYNa1-LULodaZ2p9j572qtQ4aq-wcAd07qn68shZCruryxE0xvetwO6YE-dRrMfwv8YAVTfPkaKmQ9JEjPLtEPnVU83nX8jTNvLtaI-chGGLCQlX9j7xgn9v7ArDyHSXoz9Qyc28ynmITZbtK1etbzMHD2E2n4qtUcUB_8c7Mv2IWNeNst9JkzZDG6UzPk_26DeOBGIikVAbMDdJ39gyXZRZ7oYBURLuPdftpEbweyPxBWFzKPsk-ah-31haaPEkjTTMY6p5me42LkyzD7Xx0UznoeIKyfOnQaDQmEYVABerbZgbhXLVH36oe4j5UQY5TMywCjl7JrkbVv2X8R2DqkTj5m9RJe3Iu37pYum5nVWBO8CuluJzN29OR5q8EvtwjBd_gOuzkBWePsZSyiqSzpz7qMJHwCBHtQQsqETfVOk-dSMTTlRw_Rz90vVhynfMmMIZnY1-5muwDJzjrL8LrL8La_x7WfDZupSw2Rm4aatGOSotda_QYTlJdmCbVh9C-j0AeYpbTdsgzMBnRfct5HIqrAXmF6tqictIO48m59s5ptKCBvk1PDb0iygsLo-LBWu_l5x1E_CZ_pTpEXgXzDskIQBPsCMSARJ9REQiIRaSZx64RajR1iIFbPYKwFSC6aSlTFJ_zlP1H6E7IrLDs7lCU0bcRYgduwT8CJsoHaKEGxeGC_vFThABi7rSK3ErJzirkFzDo0J6ZihM5saAhkXMfdCQrc4d9GdvqVYcRUF-gVvF88aNOMa-R5VPMrXWCvuP3ryfHOUhGiwQ5nXafb3j-Asj6iMh_r2IrSe5j9MS4P_f5Q4LPuo1i-7Crtzh2s8-6ZsdNUyyLcu5s0jKllvTbTmA9eCnhIjoasBA3SivSjZkF_gxH2upJarL9Hm_Vy8da8REPgylKsanMuztWVLZcIe4yySitopx78RFvk23MpiOFpWqKR-_6YNR6XvLKs7GEgSDCm6HRjvZAim9xaCfOpDpWpL6-BlSNKN03aBTlaPTBUm8Pm_5SbBZPVmw42gP7fn9Ix5tsGPuRRkGDlOLJXA0mgT2KghRCg

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2023; you can also visit the original URL. The file type is application/pdf.

Quantitative methods were set up to measure the conversion of C3PA or GBG to C3A or GGG. The results were compared to those of hemolytic tests by using glutathion-treated red cells. The kinetics of C3PA conversion induced in serum either spontaneously by addition of magnesium, or by various natural activators, was studied. Particular interest was given to the activation of C3PA by immune complexes. It was found that some small complexes formed in large antigen excess can activate the C3A
more » ... Similar results were obtained with complexes formed of IgA immunoglobulins and DNP-substituted antigens. The C3-converting activity of some "nephritic factors" isolated from sera of membrano-proliferative glomerulonephritis patients seems to be related to a similar activation process of the alternate pathway. (Work supported by Swiss National Research Foundation (Grant 3.617.71) and the Annette Kade Foundation.)
doi:10.4049/jimmunol.111.1.307.b fatcat:c3fafwngn5f4jmbagqapkbevta
Citation

Paul H. Lambert, L. Perrin, J. C. Cerottini. "Quantitative Studies of the Conversion of C3PA (GBG) to C3A (GGG)." Journal of Immunology (1973) 307-307