Synthesis of 1,2,4-triazine derivatives as potential anti-anxiety and anti-inflammatory agents

Pooja Mullick, Suroor A Khan, Tauseef Begum, Surajpal Verma, Darpan Kaushik, Ozair Alam
Acta Poloniae Pharmaceutica - Drug Research  
A series of 1,2,4-triazine derivatives Va (1-24) and Vb (1-24) were synthesized and evaluated for their anti-anxiety and anti-inflammatory activities. The structures of the synthesized compounds were confirmed on the basis of their spectral data. Many of the triazine compounds were found to possess good activity. Especially, compounds bearing the sulfur atom showed better activity than those bearing the oxygen atom.
pmid:19702169 fatcat:atbroeogjvd2zivxvujlpxjjq4