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Synthesis of some natural sulphonamide derivatives as carbonic anhydrase inhibitors
2017
Organic Communications
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Carbonic anhydrase inhibitors are both in clinical use as antiglaucoma, diuretics, antiepileptics and management of altitude sickness, and under investigation as anticancer, anticonvulsant and antiobesity agents. Sulphonamides have been known for decades as carbonic anhydrase inhibitors and are in clinical use. Sulphonamide derivatives of p-hydroxybenzoic acid and 3,4,5-trihydroxybenzoic acid (gallic acid) were synthesized and their inhibition values over hCA I and hCA II isozymes, purified
doi:10.25135/acg.oc.4.16.05.418
fatcat:ftt7tj6kufh5nnnprjz2pnskp4