Proteomic profiling of canine osteosarcoma patients [post]

2019 unpublished
Canine osteosarcoma (OSA) is an aggressive primary bone tumor in dogs. Metastasis of canine OSA occurs mainly in the lungs through the hematogenous route. Identification of the proteins that are associated with metastasis using proteomic technologies is important not only for the discovery of OSA targets and signaling pathways associated with metastatic OSA but also to provide novel therapeutic targets. The objective of this study was to conduct a proteomic profiling analysis of canine OSA
more » ... of canine OSA patients. We used mass spectrometry to examine the protein profiles.Results We found the overexpression of five proteins from OSA tissues-myosin (MYO7a), GTPase IMAP family member 5 isoform 1 (GIMAP5), PR domain 15 (PRDM15), A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), and interleukin receptor type
doi:10.21203/rs.2.16234/v1 fatcat:jhrtxn4jqnegdjyelb73slfdd4