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Canine osteosarcoma (OSA) is an aggressive primary bone tumor in dogs. Metastasis of canine OSA occurs mainly in the lungs through the hematogenous route. Identification of the proteins that are associated with metastasis using proteomic technologies is important not only for the discovery of OSA targets and signaling pathways associated with metastatic OSA but also to provide novel therapeutic targets. The objective of this study was to conduct a proteomic profiling analysis of canine OSAdoi:10.21203/rs.2.16234/v1 fatcat:jhrtxn4jqnegdjyelb73slfdd4