CINNAMON BARK EXTRACT FOR THE FORMULATION AND CHARACTERISATION OF ANTIMICROBIAL CREAM

Rasha Saad Suliman, Heyam Ali, Intan Nurulain, Nik Nur Shamiha, Mohamad Nizam, Sri Budiasih, Rania Suliman, Asma Al Gebaly
2017 International Journal of Research in Ayurveda and Pharmacy  
The main objective of this study was to formulate a stable W/O cream containing different strength of methanolic Cinnamomum cassia extract. It is known that the methanolic extract has an antibacterial activity and antioxidant, anticancer, antidiabetic and anti-cholesterol properties. Dried cinnamon bark was collected from Shah Alam, Malaysia during February 2014 and authenticated at Botany department at University Putra Malaysia. The dried barks were grinded to powder and used for extraction
more » ... d for extraction using maceration method. The extract was assessed for antibacterial properties. Then, a set of creams were prepared from the extract in different compositions to the formulations and stored at different accelerated conditions for a period of four weeks to predict the stability of these creams. Evaluation of creams was based on the physical stability, phase separation, centrifugation, pH of the formulations and test for microbial growth in formulated creams parameters. The result of the study showed significant changes in the pH of all creams in temperature above 25 °C and insignificant changes in temperature below 25°C with the passage of time. Great stability was observed in the formulations in term of phase separation, liquefaction, and color. The pH of all the formulations was 5.9-6.36, which is comparable to the 5-7 pH level of the skin. All these formulations showed no phase separation and color change during the test period, except for cream with 4%. From the present study, it can be concluded that it is possible to develop creams containing Cinnamomum cassia herbal extracts with a good antibacterial property.
doi:10.7897/2277-4343.082113 fatcat:j25igjh53nehfn5on42hswn2le