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WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility
2020
PLoS Genetics
Cell motility is governed by cooperation between the Arp2/3 complex and nucleation-promoting factors from the Wiskott-Aldrich Syndrome Protein (WASP) family, which together assemble actin filament networks to drive membrane protrusion. Here we identify WHIMP (WAVE Homology In Membrane Protrusions) as a new member of the WASP family. The Whimp gene is encoded on the X-chromosome of a subset of mammals, including mice. Murine WHIMP promotes Arp2/3-dependent actin assembly, but is less potent than
doi:10.1371/journal.pgen.1008694
pmid:32196488
fatcat:tffhjsje4bfqdjkxeyrqazg7cm