Accelerating chemical exchange saturation transfer (CEST) MRI by combining compressed sensing and sensitivity encoding techniques

Hye-Young Heo, Yi Zhang, Dong-Hoon Lee, Shanshan Jiang, Xuna Zhao, Jinyuan Zhou
2016 Magnetic Resonance in Medicine  
Purpose-To evaluate the feasibility of accelerated chemical-exchange-saturation-transfer (CEST) imaging using a combination of compressed sensing (CS) and sensitivity encoding (SENSE) at 3 Tesla. Methods-Two healthy volunteers and six high-grade glioma patients were recruited. Raw CEST image k-space data were acquired (with varied radiofrequency saturation power levels for the healthy volunteer study), and a sequential CS and SENSE reconstruction (CS-SENSE) was assessed. The MTR asym (3.5ppm)
more » ... gnals were compared with varied CS-SENSE acceleration factors. Results-In the healthy volunteer study, a CS-SENSE acceleration factor of R = 2×2 (CS × SENSE) was achieved without compromising the reconstructed MTR asym (3.5ppm) image quality. The MTR asym (3.5ppm) signals obtained from the CS-SENSE reconstruction with R = 2×2 were well preserved compared to the reference image (R = 2 for only SENSE). In the glioma patient study, the MTR asym (3.5ppm) signals were significantly higher in the tumor region (Gd-enhancing tumor core) than in the normal-appearing white matter (p < 0.001). There was no significant MTR asym (3.5ppm) difference between the reference image and CS-SENSE-reconstructed image in the acceleration factor of R = 2×2. Conclusion-Combining the SENSE technique with CS (R = 2×2) enables considerable acceleration of CEST image acquisition and potentially has a wide range of clinical applications.
doi:10.1002/mrm.26141 pmid:26888295 pmcid:PMC4988943 fatcat:zvb6xvpysjcotfc3xbl7vwkkoy