Extranuclear SUMOylation in Neurons

Jeremy M. Henley, Ruth E. Carmichael, Kevin A. Wilkinson
2018 Trends in Neurosciences  
General rights This document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: Abstract Posttranslational modification of substrate proteins by conjugation of SUMO regulates a diverse array of cellular processes. While predominantly a nuclear protein modification, there is growing appreciation that SUMOylation of proteins outside the nucleus plays direct roles in controlling synaptic
more » ... ssion, neuronal excitability and adaptive responses to cell stress. Furthermore, alterations in protein SUMOylation are observed in a wide range of neurological and neurodegenerative diseases, and several extranuclear disease-associated proteins have been shown to be directly SUMOylated. Here, focusing mainly on SUMOylation of synaptic and mitochondrial proteins, we outline recent developments and discoveries, and present our opinion as to the most exciting avenues for future research to define how SUMOylation of extranuclear proteins regulates neuronal and synaptic function.
doi:10.1016/j.tins.2018.02.004 pmid:29530319 fatcat:3r2dchxg7rdr3bxfdxg2tpmywq