Carbonylative annulation of unsaturated compounds using molybdenum hexacarbonyl: an efficient synthesis of 2(1H)-quinolones

2014 ARKIVOC  
A ligand-and CO gas-free condition is developed in palladium-catalyzed three-component reaction of iodoanilines, unsaturated compounds and Mo(CO) 6 as a solid carbon monoxide source. The approach allows for smooth construction of biologically interesting 3,4-disubstituted (dihydro)quinolin-2(1H)-ones in presence of catalytic amounts of palladium and avoids the problematic use of gaseous carbon monoxide.
doi:10.3998/ark.5550190.p008.531 fatcat:ebdtcc6ab5emnix4s3soug5p5i