Where's the Mouse Info?

J. P. Sundberg, J. M. Ward, P. Schofield
2009 Veterinary pathology  
The laboratory mouse has long been the species of choice for many animal models of human diseases. In part, this is due to the long-standing genetic resources available for the mouse, but now also the development of powerful new techniques for generation of mutations, analysis of complex traits, and high throughput data gathering, have made the mouse the preeminent model for the study of human biology and disease. 34 With the completion of the mouse genome sequence, it is now possible to
more » ... generate knockouts and knock-in mutations anywhere in the genome, either constitutively or conditionally using Creand Flp-mediated recombination, alterations in gene, or locus copy number. Complex trait analysis now permits the underlying spontaneous genetic predisposition to multigenic diseases to be elucidated. The increased sophistication and miniaturization of physiological monitoring and diagnostic instrumentation mean that the depth of phenotype data that can be collected is unprecedented.
doi:10.1354/vp.09-vp-0042-s-com pmid:19605899 pmcid:PMC3804057 fatcat:eeorzzoffndktigjbylo3qqp7e