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Ultrastructural examinations of the cerebral vascular wall following subarachnoid hemorrhage (SAH) demonstrated that collagen fibrils developed in the muscle layer near the adventitia in the early stage of SAH and increased in number and volume with time. These findings suggest that accelerating factors of collagen synthesis in the muscle layer may be released from the adventitial side, and collagen syn thesis is induced by extravascular factors. The changes of collagen volume with time suggestdoi:10.2176/nmc.32.877 pmid:1282677 fatcat:6bbtsa7345fdzobzwi2lmhzbaa