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Differential Effects of Insufflated, Subcutaneous, and Intravenous Growth Hormone on Bone Growth, Cognitive Function, and NMDA Receptor Subunit Expression
Journal of Clinical Endocrinology and Metabolism
The objective of this study was to characterize the effect of inhalable growth hormone (GH) delivered by an insufflator to the lungs of hypophysectomized Sprague Dawley rats. In the first cohort, the safety and efficacy of the insufflated GH were evaluated. Three experimental groups (n ϭ 7 per group) were treated with GH for 15 d: One group received sc injection of GH daily at 200 g/kg (SC200). Two other groups received GH by insufflation daily: 200 g/kg (INS 200) and 600 g/kg (INS 600). In thedoi:10.1210/jcem.95.8.9982 fatcat:kdn33lmehvhzheplx4mz3pbnxa