Association of alpha-1 antitrypsin level and lung function in patients with chronic obstructive pulmonary disease

Danielius Serapinas, Ruta Nutautiene, Ruta Pukinskaite, Daiva Bartkeviciene, Diana Barkauskiene, Raimundas Sakalauskas
2017 Srpski Arhiv za Celokupno Lekarstvo  
Introduction/Objective Alpha-1 antitrypsin deficiency is a well established inherited risk factor for chronic obstructive pulmonary disease (COPD); however, alpha-1 antitrypsin level may result in different lung function reduction. The aim of our study was to evaluate possible associations of alpha-1 antitrypsin level and lung function in COPD patients with different alpha-1 antitrypsin phenotypes. Methods Serum alpha-1 antitrypsin concentration from patients (n = 1,167) with COPD, defined
more » ... COPD, defined according to the GOLD criteria, were analyzed by nephelometry, and alpha-1 antitrypsin phenotype was determined by means of isoelectric-focusing. Results In COPD patients without alpha-1 antitrypsin deficiency (MM), a significant negative association of lung function (FEV 1 ) with serum alpha-1 antitrypsin (r = -0.511; p < 0.05) and C-reactive protein (CRP) concentrations (r = -0.583; p < 0.05) was detected; moreover, the level of alpha-1 antitrypsin positively correlated with CRP concentration (r = 0.667; p < 0.05). Conclusions In patients without alpha-1 antitrypsin deficiency, detected negative association of alpha-1 antitrypsin level with FEV 1 and positive association with the CRP level defined the importance of alpha-1 antitrypsin for lung function in COPD patients.
doi:10.2298/sarh160809148s fatcat:lnxejh6zgffanivxwqjr6all2u