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Mrs. J is a 45-year-old woman with metastatic breast cancer. Her cancer has proved resistant to several standard chemotherapy treatments. Her doctor has become aware of a new clinical trial, which offers whole genome sequencing of the patient's tumor to select treatment based on specific mutations found in the cancer. To properly interpret somatic mutations found in the tumor, the study also requires a sample of germline DNA. Mrs. J agrees to participate in the trial. Several weeks later,doi:10.1001/virtualmentor.2013.15.8.stas1-1308 pmid:23937784 fatcat:t5re25fnkzc7ngum5iqpexsg6m