and aims: Egypt has the largest burden of hepatitis C infection & liver cirrhosis worldwide. Sixty percent of cirrhotic patients develop esophageal varices and thirty percent suffer variceal hemorrhage. Studying portal hemodynamics using duplex Doppler is non-invasive, reliable and relatively cheap method for evaluating portal hemodynamic changes in cirrhotic patients; also it can be used in studying the effect and prognosis of different drugs used to reduce portal hypertension. Whereas Baveno

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... onsensus conference recommends β-blockers, banding ligation or both; the experts add that combined therapy is probably the best. Aim Of The Work: was to study portal hemodynamics in cirrhotic patients with esophageal varices admitted for band ligation with and without the administration of propranolol. Patients And Methods: 50 patients eligible for the study (cirrhosis, esophageal varices and no contraindications for propranolol), were randomized into two groups: Group I: 25 patients on oral propranolol (non-selective β-blocker) combined with endoscopic variceal band ligation. Group II: 25 patients on endoscopic variceal band ligation alone without oral propranolol. RESULTS: As regards to Portal vein diameter (PVD), Portal vein flow velocity (VEL), and Congestion index (CI) , there was no statistically significant difference between the two groups before the start of the treatment. After 6 months of treatment, there was statistically significant difference between the two studied groups as regards to PVD & VEL, while non-statistically significant difference for CI. Conclusions: both band ligation and propranolol reduced portal hemodynamic parameters, but patients on combination of both showed better results.