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Journal of Virology
The human papillomavirus E7 gene product is an oncoprotein with properties similar to those of the adenovirus ElA proteins. The human papillomavirus E7 proteins possess substantial amino acid sequence similarity to portions of conserved regions 1 and 2 of ElA, and the human papillomavirus type 16 E7 protein trans-activates the adenovirus E2 early promoter. Analysis of point mutations in the E2 promoter indicated that the E2F recognition sites were critical to E7 stimulation. In contrast to thedoi:10.1128/jvi.65.12.6922-6930.1991 fatcat:rznxd4msgfelxiqywiasw4qnwa