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Journal of Virology
Treatment of poliovirus Type I with 10-3 M 2-thiouracil (2-TU) resulted in the inactivation of greater than 90% of the virus infectivity and stabilization of approximately 50% of the residual virus to heat inactivation. These effects were due to a reaction with the protein moiety of the virus and could be blocked by pretreatment of the virus with L-cystine or of the drug with cysteine. Both inactivation and stabilization occurred synchronously and reached equilibrium at the same time. Neitherdoi:10.1128/jvi.1.4.653-658.1967 fatcat:ydu5kefs45d63fsgalcotrbtm4