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CD82 encodes a transmembrane glycoprotein of tetraspanins family, and functions as a tumor metastasis suppressor. We performed a systematic meta and bioinformatics analysis through multiple online databases up to March 14, 2017. We¬ found down-regulated CD82 expression in gastric cancer, compared with normal mucosa (p < 0.05). CD82 expression was negatively with depth of invasion, lymph node and distant metastasis, TNM staging and dedifferentiation of gastric cancer (p < 0.05). A positivedoi:10.18632/oncotarget.21993 fatcat:3scpdbltirgfzh4tzb5rlb4abm