Increased Serum Level of Interleukin-5 in a Patient with Episodic Angioedema and Eosinophilia Syndrome

Tsuzuku MURAKAMI, Junji KATO, Katsuhisa KOGAWA, Naoki WATANABE, Sumio SAKAMAKI, Yutaka KOHGO, Kou HAMABE, Naoshi ISHIYAMA, Hideo ENOKIHARA, Yoshiro NIITSU
1993 Internal medicine (Tokyo. 1992)  
A case of episodic angioedema and eosinophilia syndrome is reported. An 18-year-old male suffered from monthly episodes of angioedema, pruritic papules, weight gain, and fever for twelve years. During the episodes, peripheral eosinophils and serum levels of interleukin (IL)-5, an eosinophil proliferating cytokine were elevated. Extensive evaluations disclosed neither visceral involvement nor evidence of parasitic infections, collagen diseases, or neoplastic disorders. Corticosteroid treatment
more » ... steroid treatment brought about a dramatic clinical improvement concomitant with decrement of eosinophils and serum IL-5 was observed. These observations suggest that IL-5 may be a causative factor for this pathological state. (Internal Medicine 32: 343-345, 1993)
doi:10.2169/internalmedicine.32.343 fatcat:7ff5ia2wnzeylevlxobb4cklsy