Prophylaxis for Hepatitis B Core Antibody-Positive Donors after Liver Transplantation

Hee-Yeon Kim, Jong-Young Choi
2010 The Journal of the Korean Society for Transplantation  
The growing shortage of organs for orthotopic liver transplantation (OLT) has led to an expanded donor pool with the use of marginal grafts. Recipients who receive liver grafts from HBsAg-negative, anti-HBc positive donors have an increased risk of developing de novo hepatitis B infection. This review covers several issues in liver transplantation using hepatitis B core antibody-positive donors: (1) the mechanism of de novo hepatitis B infection, (2) high risk groups, (3) prophylactic regimens
more » ... phylactic regimens and (4) clinical significance and a proposal for patients in Korea.
doi:10.4285/jkstn.2010.24.2.73 fatcat:pfcuds4fe5d3loi457ylugzttm