Adverse Effects of Medications on Periodontal Tissues [chapter]

Sukumaran Anil, Seham H.S.A. Alyafei, Annie Kitty George, Elna Paul Chalisserry
2020 Oral Diseases [Working Title]  
Periodontal tissue is susceptible to a range of adverse effects of several medications used in daily medical practice. Phenytoin, cyclosporine, and calcium-channel blockers are the most commonly used drugs related to gingival disease. Several other medications can also have an adverse effect on the periodontium, especially in the presence of compromised oral hygiene. These medications act on periodontal tissues by triggering the inflammatory pathways involved in the pathogenesis of periodontal
more » ... sis of periodontal disease or by potentially compromising the management of patients with these conditions. Gingival overgrowth is probably the mostly widely recognized and investigated type of adverse drug reaction in the periodontal tissues. Since many patients are on such medications, dental practitioner should take a thorough medical history and be aware of medication-related problems and their potential effects on diagnosis and treatment planning. The chapter reviews the commonly prescribed medications that can affect the periodontium either in its healthy or inflamed condition. 2 2. Drug induced gingival overgrowth (DIGO) DOI: http://dx.and clopidogrel which are often used in combination. Both of these drugs have been reported to cause increased gingival bleeding. Patients on these medications carry a risk of an increased tendency to bleeding during or following periodontal surgery and this risk is far greater when the drugs are used in combination [94] .
doi:10.5772/intechopen.92166 fatcat:63zx5viiazf7bkxfvxoc5mfy6y