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Objective: To assess the safety of conscious sedation in patients undergoing endoscopic retrograde cholangio pancreaticography (ERCP). Methodology: All patients underwent ERCP procedure under midazolam and/or nalbuphine were included. Safety was assessed by monitoring the hemodynamics and complications during procedure till discharge from hospital. SPSS version 20 was used for descriptive analysis. Results: A total of 550 procedures were enrolled for the study. The mean age of the patients wasdoi:10.29271/jcpsp.2018.12.950 fatcat:fwhsoo4s6zad5h3kzjgbyj7n6i