The cytokeratin 18, adiponectin and leptin levels in patients with non-alcoholic steatohepatitis and coronary heart disease

Oksana S. KHUKHLINA, Olha B. KUZMINSKA, Alona A. ANTONIV, Tamara H. KOPCHUK, Svitlana P. MELNYCHUK, Department of Internal Medicine, Clinical Pharmacology and Occupational Diseases, Higher State Educational Institution of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine", " Department of Internal Medicine, Clinical Pharmacology and Occupational Diseases, Higher State Educational Institution of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine", " Department of Internal Medicine, Clinical Pharmacology and Occupational Diseases, Higher State Educational Institution of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine", "Department of Pharmacology, Higher State Educational Institution of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine", "Department of Pharmacology, Higher State Educational Institution of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine"
2019 Archives of the Balkan Medical Union  
Le contenu de la cytokératine 18, de l'adiponectine et de la leptine chez des patients atteints d'une stéatose hépatique non alcoolique chronique et cardiopathie ischémique But: déterminer le niveau de cytokératine 18, d'adiponectine et de leptine dans le plasma des patients atteints de NASH et leur association avec le degré de cytolyse, la violation du métabolisme des glucides et des lipides lors de la comorbidité avec une cardiopathie ischémique. Matériel et méthodes: Soixante patients
more » ... nte patients atteints de NASH ont été examinés et divisés en 2 groupes : 1er groupe -30 patients atteints de NASH sur fond d'obésité degré I-II, 2ème groupe -30 patients atteints de NASH avec coronaropathie (angor stable II et II) et obésité I-II degré. L'âge moyen des patients était de 55,13±6,34 ans. Le groupe témoin était composé de 20 personnes pratiquement en bonne santé. La détermination du taux de cytokératines 18, d'adiponectine et ABSTRACT The aim of the study was to determine the level of cytokeratin 18, adiponectin and leptin in plasma of the patients with nonalcoholic steatohepatitis (NASH) and coronary heart disease (CHD) and their association with the degree of cytolysis, disorders of carbohydrate and lipid metabolism. Materials and methods. We examined 60 patients with NASH, who were divided into 2 groups: group 1 -30 patients with NASH on the background of obesity of 1st-2nd degree, group 2 -30 patients with NASH and CHD (the 1st and 2nd functional classes of stable angina pectoris) and obesity of 1st-2nd degree. The mean age of patients was 55.13±6.34 years. The control group consisted of 20 practically healthy persons (PHP). Serum CK18, adiponectin and leptin levels were determined by the immunoassay analysis. Results. Our research showed that NASH is closely associated with disorders of adipocytokine homeostasis. In patients with NASH, comorbid CHD, and obesity of 1st-2nd degree, there is an increase level of CK
doi:10.31688/abmu.2019.54.3.09 fatcat:cdw5ajb6azdv3czjmni5j5zbby