THE COMBINED EFFECT OF DEXAMETHASONE AND BACILLUS CALMETTE–GUÉRIN ON THE NEUROBEHAVIORAL ASPECT IN MALE MICE (MUS MUSCULUS)

ABDELKRIM HAOULI, SAMIR DJEMLI, ABDELKRIM TAHRAOUI
2019 Asian Journal of Pharmaceutical and Clinical Research  
Objective: Our study aims to evaluate the combined effect of Bacille Calmette–Guérin (BCG) and dexamethasone (DEX) on male mice undergoing behavioral testing (forced swimming test, elevated plus maze, tail suspension test, and sucrose intake). An intraperitoneal injection of 0.2 ml/mg of BCG and 0.1 ml/mg of DEX body weight was administered after all behavioral tests were applied. Methods: This study is based on the distribution of 15 male mice in three groups: Controls, DEX, and DEX+BCG. These
more » ... and DEX+BCG. These mice underwent behavioral tests. Results: The result after administration of DEX and BCG was found after 10 days. We observed an increase in locomotors activity with some degree of anxiety. Conclusion: This allowed us to conclude that the combination of DEX+BCG seems to play a depressinogenic effect that will develop to become antidepressive.
doi:10.22159/ajpcr.2019.v12i18.32609 fatcat:usxtempr2zh4fhoucvfe6pbssq