Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae)

Jeferson S. Santana, Patricia Sartorelli, João Henrique G. Lago, Alisson L. Matsuo
2012 Química Nova  
Recebido em 27/4/12; aceito em 1/8/12; publicado na web em 25/9/12 ISOLATION AND EVALUATION OF CYTOTOXIC POTENTIAL OF PHENOLIC DERIVATIVES FROM Schinus terebinthifolius Raddi (Anacardiaceae). The EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H 2 O and hexane, CH 2 Cl 2 , and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1),
more » ... llic acid (1), methyl (2) and ethyl (3) gallates, trans-catechin (4), quercitrin (5), and afzelin (6) , being the first occurrence of 1, 4 and 6 in S. terebinthifolius. In vitro cytotoxic evaluation of 1 -6 indicated that gallic acid (1) displayed higher activity than ethyl gallate (3) against HL-60 and HeLa cells, while compounds 2, 4 -6 were inactive.
doi:10.1590/s0100-40422012001100029 fatcat:c5443butmndvrexxxrhfnygk7q