Therapeutic Interventions in Adult Low-Grade Gliomas

Majid Chammas, Fadi Saadeh, Maya Maaliki, Hazem Assi
2019 Journal of Clinical Neurology  
1 Treating adult low-grade gliomas (LGGs) is particularly challenging due to the highly infiltrative nature of this type of brain cancer. Although surgery, radiotherapy, and chemotherapy are the mainstay treatment modalities for LGGs, the optimal combination management plan for a particular patient based on individual symptoms and the risk of treatment-induced toxicity remains unclear. This review highlights the competency and limitations of standard treatment options while providing an
more » ... roviding an essential therapeutic update regarding current clinical trials aimed at implementing targeted therapies with morbidity rates lower than those for current LGG treatments and also augmenting the killing of cancerous cells while maintaining an improved quality of life. cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. JCN Open Access REVIEW www.thejcn.com 7 Chammas M et al. JCN cancer cells but may also enhance the quality of life of these patients, a factor that has not been studied extensively in the past due to a focus on treating the underlying pathology. Such better outcomes might be achievable as medicine evolves toward more-personalized therapies.
doi:10.3988/jcn.2019.15.1.1 fatcat:gfnomgl4dzhmxahgea2uqcl3pe