Congenital toxoplasmosis from a chronically infected woman with reactivation of retinochoroiditis during pregnancy – an underestimated event?

Gláucia M. Q. Andrade, Daniel V. Vasconcelos-Santos, Ericka V. M. Carellos, Roberta M. C. Romanelli, Ricardo W. A. Vitor, Ana C. A. V. Carneiro, Jose N. Januario
2009 Jornal de Pediatria  
Objective: To report a rare case of congenital toxoplasmosis from an immunocompetent mother with chronic infection who had reactivation of ocular disease during pregnancy. Description: The newborn was asymptomatic at birth and identified by neonatal screening (IgM anti-Toxoplasma gondii in dried blood) among other 190 infants with congenital toxoplasmosis during a 7-month period. His mother had had a non-treated episode of reactivation of toxoplasmic retinochoroiditis during pregnancy, with
more » ... pregnancy, with stable IgG titers and negative IgM results. Results of IgM and IgG in the newborn's serum, as well as IgG immunoblotting were positive and active retinochoroidal lesions were detected in his peripheral retina. The neonate was treated with sulfadiazine, pyrimethamine and folinic acid. At 14 months of life, the child remained asymptomatic, with regression of retinochoroidal lesions and persistence of IgG. Comments: It is possible that systematic neonatal screening in areas with high prevalence of infection may identify these cases. J Pediatr (Rio J). 2010;86(1):85-88: Congenital toxoplasmosis, vertical transmission, neonatal screening, chorioretinitis, pregnancy.
doi:10.2223/jped.1948 fatcat:uhrzqea3nbgyxmanb4rlyohppa