Discovery of Terbinafine Low Susceptibility Trichophyton rubrum strain in Japan

Shusaku Suzuki, Yoko Mano, Nobuhiko Furuya, Katsumi Fujitani
<span title="">2018</span> <i title="The Society for Antibacterial and Antifungal Agents, Japan"> <a target="_blank" rel="noopener" href="" style="color: black;">Biocontrol Science</a> </i> &nbsp;
This is the first confirmed report of terbinafine low susceptibility Trichophyton rubrum, BGUTR13, in Japan collected from the whole sole of the elderly over 65s with cotton swab sampling method at the special nursing care-home in 2016. We revealed BGUTR13 showed low susceptibility (MIC, >128 μg/mL) against terbinafine. But, BGUTR13 exhibited normal susceptibility to itraconazole, did not showed cross-resistance. Also, the squalene epoxidase gene of terbinafine low susceptibility strain BGUTR13
more &raquo; ... which is the target of terbinafine contained newly confirmed one mismatch. We suggested the possibility that the resistance mechanism of terbinafine low susceptibility strains is due to the loss of sensitivity of squalene epoxidase inhibitors and does not affect antifungal drugs with other different mechanisms of action.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.4265/bio.23.151</a> <a target="_blank" rel="external noopener" href="">pmid:30249966</a> <a target="_blank" rel="external noopener" href="">fatcat:m7jxiimn3nc2rfv5uj5udprphu</a> </span>
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