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The RPE65 gene was screened in 26 breeds of dogs in order to identify potential disease-causing mutations in dogs with generalized progressive retinal atrophy (gPRA). Intronic sequences were obtained from canine genomic DNA by intron-overlapping polymerase chain reactions (PCRs). Mutation analysis was performed by PCR and demonstration of single strand conformation polymorphisms (SSCP). Genomic variations were verified by sequencing. A series of exonic and intronic single nucleotidepmid:14627956 fatcat:i3kpgifsfzbrjegi2vnnlpzvta