Association of Anti - TPO Antibodies with Thyroid Dysfunction

Dr M.K. Uthaya Sankar, Department of General Medicine, Sri Manakula Vinayagar Medical College and Hospital, Puducherry-605107, India
2020 Journal of Medical Science And clinical Research  
Thyroid peroxidise (TPO) autoantibodies are a secondary response to thyroid injury and do not cause disease themselves. Though the presence of Anti TPO antibody may be a hallmark for autoimmune thyroid disease, there are reports that suggest the presence of Anti TPO antibodies can be a marker of thyroid dysfunction in future. Objective: To assess the presence of Anti -TPO antibodies in patients with thyroid dysfunction. Materials and Methods: This is a cross sectional study done on 60 Patients
more » ... one on 60 Patients above the age of 18yrs attending General Medicine OPD with history of thyroid dysfunction and were subjected to thyroid function test and measurement of anti -TPO antibodies. Results: Of the 60 patients 26 were found to be hypothyroidic, 15 were hyperthyroidic, FNAC of 7 patients suggested the presence of malignancy and 12 patients had Hashimoto's thyroiditis. A significant association was found between Anti TPO levels and trends of anaemia with a p value of 0.02. On assessing the association between thyroid function test and Anti TPO antibody level, a significant relation with a p value of 0.01 was found with trends of free T3 levels. Of the 7 patients under malignancy group, 5 patients (71.4%) who had papillary carcinoma thyroid had elevated Anti TPO antibody levels. Conclusion: In presence of Anti TPO antibodies along with a thyroid swelling a direct diagnosis of autoimmune thyroiditis should not be made and an FNAC biopsy should always be performed to rule out the likely possibility of carcinoma thyroid.
doi:10.18535/jmscr/v8i2.125 fatcat:enf6weq6vzg4lcp2mhei72oh6u