A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is
Field cancerization" was introduced in 1953 to describe histologically abnormal tissues surrounding oral squamous cell carcinoma, particularly in the upper aerodigestive tract, likely related to exposure to carcinogens. Concept now refers to multiple local and distant primary tumors within the upper aerodigestive tract, along with oral premalignant lesions. Tobacco and alcohol are independent risk factors, but when combined, they have a synergistic effect. Earliest lesions are oftendoi:10.5455/2349-2902.isj20141101 fatcat:fuupf6f77nernen3y3uhbze7ca