Extraction and carrier-facilitated transport of amino acids using synthetic non-cyclic receptors through bulk liquid membrane

Pratibha Joshi, Nidhi Joshi, Uma Sharma
2006 Indian Journal of Biochemistry & Biophysics  
The extraction and carrier-facilitated transport of amino acids (leucine, valine and glycine) was studied through chloroform bulk liquid membrane system using a series of non-cyclic receptors such as diethylene glycol (1), diethylene glycol dimethyl ether (2), diethylene glycol dibutyl ether (3), diethylene glycol dibenzoate (4), triethylene glycol (5) and tetraethylene glycol (6). The amount of amino acid extracted and transported depends mainly upon the structure and the concentration of the
more » ... ncentration of the receptors and also on the concentration of amino acid. The receptors 1 to 4, having small chain length and flexible end groups, formed stable complexes with amino acids, and the flexibility of receptors in different conformational forms was responsible for their carrier ability, while the receptors 5 and 6, having larger chain length showed poor carrier ability. Hydrophobicity of amino acids also play an important role in the extraction as well as transport process.
pmid:17133741 fatcat:3lnsn6ybuzfeba2iyhhffrwzum