DEXTROSE TOLERANCE IN ATROPHIC INFANTS
Archives of Pediatrics & Adolescent Medicine
The tolerance of individuals to sugar has been determinedpreviously by testing how much could be given by mouth or how much could be injected at one time subcutaneously or intravenously before sugar appeared in the urine. It was recognized that these methods were open to objections. In order to overcome these objections Woodyatt1 constructed an apparatus permitting a continuous intravenous injection of solutions at any desired rate. The apparatus consists of a motor driven syringe filling and
... ringe filling and discharging automatically. In this way it was possible for Sansum and Wilder22 to determine the tolerance of adults to dextrose much more accurately than had been possible before. They found that the appearance of the sugar in the urine depends on the amount of sugar injected in a unit of time, independent of the concentration of the sugar solution. The tolerance is expressed in grams of glucose which can be injected per kilogram of body weight in one hour at a uniform rate of flow, without leading to the excretion of sugar in the urine. For normal adults, dogs and rabbits this tolerance was from 0.8 to 0.9 gm. per kilogram per hour. We determined the glucose tolerance of atrophie infants by this method with the idea in mind that such infants might derive some benefit from intravenous glucose injections. The parts of the apparatus which come in contact with the fluid are sterilized by heat. A dextrose marked C. P., manufactured by the Corn Products Refining Company, was used. This is about 99 per cent. pure. The rubber tubing used is 8 mm. in diameter with a 3 mm. bore ; a 50 cc. graduated buret serves as a reservoir. A hand syringe is attached to the two-way stopcock inserted in the tubing between the pump and patient. A glass window connects the tubing with the 22 gage platinum or gold needle. In making the dilution we were guided by the fact that with our instrument the most convenient rate of injection was between 25 and 50 cc. per hour. The glucose is dissolved in freshly distilled water and arnoldized on three successive days. The strength of the solution was made approximately 10, 15 and 20 per cent. The actual concentration was determined polari-From the Otho S. A.