Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography

Kun-Ju Lin, Tzu-Chen Yen, Shiaw-Pyng Wey, Jeng-Jong Hwang, Xin-Xian Ye, Kai-Yuan Tzen, Ying-Kai Fu, Jin-Chung Chen
2004 Journal of Nuclear Medicine  
Imaging of serotonin transporter (SERT) in the central nervous system may provide an important tool to evaluate some psychiatric disorders. Recently, a novel (123)I-labeled radiotracer, 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine ((123)I-ADAM), has been developed that exhibited a high selectivity for SERT. The aim of this study was to characterize the biodistribution and specificity of (123)I-ADAM to SERT using quantitative autoradiography in both control and neurotoxin-treated animals.
pmid:15073265 fatcat:xwy24pr35bfg5gurpnbzsl5ade