The present study was undertaken to evaluate the potential protective and therapeutic effect of curcumin (Cur) on ethanol-induced gastritis in rats. Fourty male albino rats were divided into four groups. Group Ι: (Control group): received no drugs. Group Π: (Gastritis non-treated group): administered with a single oral dose of 1 ml/rat of absolute ethanol for gastritis induction. Group III: (Gastritis + Cur protected group): received Cur (100 mg/kg body weight/day) orally for 14 days prior

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... ol administration. Group IV: (Gastritis + Cur treated group) received Cur as in group III and the treatment was continued for 7 days later. The obtained results showed a significant decrease in serum nitric oxide (MPO as well as COX-2 activities. Furthermore, various pathological changes in gastric tissues were observed in gastritis induced rats. Interestingly, the severity of these alterations was reduced in curcumin protected and treated groups with variable degree. These results suggest that, Cur may be beneficial in treatment of gastritis by its radical scavenging and antiapoptotic activity, reserved inflammation, oxidative stress and regulate NF-kappaB activation and attenuate the severity of histopathological alterations in the gastric mucosa.