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Background: Gastric cancer (GC) is the fifth most common cancer in the world and the second leading cause of cancer death. Gastric cancer screening is one of the effective strategies to reduce the mortality. If we use gastric cancer biomarkers with good clinical effect instead of gastroscopy screening, it can achieve early detection, early diagnosis, early treatment. Methods: We download four gene expression profiling datasets of gastric cancer (GSE118916, GSE54129, GSE103236, GSE112369), whichdoi:10.21203/rs.3.rs-34199/v1 fatcat:as5jcnbyerecpfjtpoo72toseq