The Enhancing Effect of -Cyclodextrin Inclusion on -Tocotrienol-dependent Negative Growth Control of Mesothelioma Cells in a Xenograft Model

T. Yano, A. Sato, M. Sekine, K. Kashiwagi, M. Ota
2011 Functional Foods in Health and Disease  
Malignant mesothelioma is an aggressive cancer with no effective treatment options. Of phytochemicals, tocotrienol (T3), a member of vitamin E, is one of the most potent anti-mesothelioma agents, but the effectiveness in vivo is quite limited, due to its low bioavailability. In this study, we investigated if the oral treatment of -T3 inclusion with -cyclodextrin (CD) could improve the bioavailability and anticancer activity of the T3.Findings: Using nude mice bearing MSTO-211H cells (a human
more » ... 11H cells (a human malignant mesothelioma cell line), the effect of -T3 inclusion with -CD on -T3 level in tumor tissues, tumor growth, and its related mRNA levels were examined. The difference of tumor growth between the two groups had no statistical significance, but the latter showed a lower tendency compared with the former. In linked with this observation, the level of vascular endothelial growth factor mRNA required for in vivo tumor growth in -T3 inclusion with -CD group was lower than that in -T3 group, on the contrary, the level of -T3 level showed an opposite tendency.Conclusion: Our study demonstrated that the bioavailability of -T3 was improved by an oral administration of a novel -T3 inclusion complex with CD. Furthermore, the improvement of the bioavailability contributed to the increase of anticancer activity of -T3 in vivo.Key words: Anti-cancer agent, bioavailability, cyclodextrin, mesothelioma, tocotrienol.
doi:10.31989/ffhd.v1i12.110 fatcat:qak7ibqulvdm3lvajjysr3yrii